The calcium invasion: Calciphylaxis in Lupus.

Association between calciphylaxis and inflammation in two patients on chronic dialysis.

The pathogenesis of calciphylaxis, which has a rising incidence in the chronic dialysis population and a high mortality rate, is poorly understood. Abnormalities in the calcium-phosphorus-parathyroid axis are clinically related to calciphylaxis, but alone, they cannot explain this condition. Here, we present two patients who had chronic inflammatory conditions and hyperparathyroidism and who de...

Facial calcinosis cutis in a patient with systemic lupus erythematosus: A case report of tissue injury owing to photosensitivity as the cause of dystrophic calcification

SLE: systemic lupus erythematosus INTRODUCTION Soft tissue calcification (calcinosis cutis) is a rare disorder with 5 different subtypes: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Dystrophic calcinosis refers to the deposition of calcium in areas of prior tissue injury in patients with normal serum calcium and phosphorus. Dystrophic calcification has been associated wit...

Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation.

BACKGROUND Calciphylaxis and calcinosis can both cause severe morbidity and mortality in patients with systemic lupus erythematosus (SLE). Haematopoietic stem cell transplantation (HSCT) has been successfully used to treat patients with refractory SLE. It was hypothesized that in calciphylaxis and calcinosis, ongoing inflammatory activity contributes to the calcium deposition in the media of sm...

Sodium Thiosulfate: An Emerging Treatment for Calciphylaxis in Dialysis Patients

Calciphylaxis is a rare but life-threatening complication seen in dialysis patients. We report a case with calciphylaxis and severe secondary hyperparathyroidism. Sodium thiosulfate (STS) was used for treatment in this case. The painful skin ulcers improved significantly soon after treatment, with a slight reduction in the calcium-phosphorus product. Total parathyroidectomy was carried out 6 mo...

A Fatal Case of Calciphylaxis in a Patient with Systemic Lupus Erythematosus and Normal Renal Function.